Kumamoto - Wales coach Warren Gatland has made 13 changes to the team that came through a bruising win against Fiji for their final Rugby World Cup Pool D match against Uruguay here on Sunday.
Only centre Hadleigh Parkes and winger Josh Adams, who scored a hat-trick of tries in the ferocious 29-17 victory over the Fijians, remain from that starting XV.
Rhys Patchell starts at flyhalf, after Dan Biggar's head injury against Fiji, with scrum-halves Tomos Williams and Gareth Davies on the bench as the only backline cover.
Wales have already secured a quarter-final spot, along with Australia, after previously beating Georgia (43-14) and the Wallabies (29-25).
Sunday's match looks unlikely to be cancelled because of incoming Typhoon Hagibis because it is in Japan's south-west, out of the projected path of the storm.
"We've got to make sure we do a job early on against Uruguay," Gatland told reporters. "It's challenging with such a short turnaround but that's what World Cups are all about.
"The squad is in a good place mentally. There are a group of players that are excited.
"We're expecting another tough game but also a good performance."
Openside flanker Justin Tipuric will skipper the team against Uruguay, in a back row also featuring Aaron Shingler and Aaron Wainwright.
Ospreys duo Bradley Davies and Adam Beard will pack down in the second row, the latter making his first appearance in Japan after recovering from having his appendix out on the day he was meant to fly out.
Nicky Smith, Ryan Elias and Dillon Lewis are named in the front-row, while Aled Davies and Patchell will partner at half-back with Parkes and Owen Watkin comprising the midfield.
Hallam Amos and Leigh Halfpenny come into the back three alongside Adams.
On the bench Elliot Dee, Rhys Carre and Wyn Jones provide the front-row cover with Jake Ball, Ross Moriarty and James Davies also amongst the replacements. Scrumhalves Williams and Gareth Davies are the reserve backs.
"It's a bit of a juggling act," acknowledged Gatland. "We knew from the start that we were going to expose a few players.
"We knew we'd go into this game with one 10 so we've been looking at cover there.
"We have a fresh forward pack and they're excited and looking forward to the opportunity. The door is not shut. Players can stake a claim for quarter-finals."
Uruguay caused one of the upsets of the tournament when they edged a second-string Fiji side 30-27, something not lost on Gatland.
"It was a great win over Fiji. They deserved their celebrations. It was great to see and it was good for rugby," the Kiwi coach said.
"They've defended well and they look like a fit side.
"In the games, they've been tough. They've got a good set piece and they like to play some attacking rugby."
The Wales-Uruguay match on Sunday is expected to escape any fallout from the typhoon set to hit eastern Japan 24 hours earlier, which has led to the cancellation of Saturday's England-France and New Zealand-Italy games.
"We knew from the start that this was a possibility, if a typhoon came then games could be off," said Gatland.
"It's disappointing for the fans and some of the teams involved as well.
"We're just concentrating on ourselves and hoping to finish on top of this group."
15 Leigh Halfpenny, 14 Josh Adams, 13 Owen Watkin, 12 Hadleigh Parkes, 11 Hallam Amos, 10 Rhys Patchell, 9 Aled Davies, 8 Aaron Wainwright, 7 Justin Tipuric (captain), 6 Aaron Shingler, 5 Adam Beard, 4 Bradley Davies, 3 Dillon Lewis, 2 Ryan Elias, 1 Nicky Smith
Substitutes: 16 Elliot Dee, 17 Rhys Carre, 18 Wyn Jones, 19 Jake Ball, 20 Ross Moriarty, 21 James Davies, 22 Tomos Williams, 23 Gareth Davies