Tokyo - England coach Eddie Jones announced 10 changes on Tuesday for this week's Rugby World Cup match against the USA on Thursday, benching playmaker Owen Farrell and resting centre Manu Tuilagi.
Flyhalf George Ford captains the side in Farrell's absence on Thursday and will look to unleash a new-look back line that includes Bath sevens specialist Ruaridh McConnochie on the wing for his second cap.
England have plenty of power on the other wing as well, with Fijian-born Joe Cokanasiga making his World Cup debut and weighing in at 122 kilogrammes. Elliot Daly keeps his place at full back.
Willi Heinz gets a run out at scrumhalf but Ben Youngs will equal England legend Jonny Wilkinson's tally of 91 Test caps if he comes off the bench.
Up front, prop Dan Cole will also win his 91st cap and packs down in the front row with Joe Marler and Luke Cowan-Dickie, who scored England's bonus-point try in the 35-3 opening match against Tonga.
Billy Vunipola is risked at number eight alongside Tom Curry, who was impressive in England's opener, and Lewis Ludlam.
The last time England made 10 changes was in 2003, a tournament they went on to win.
Even with the changes, England should have too much class for the Eagles and with a four-day turnaround from their bruising encounter with Tonga, probably have half-an-eye on sterner tests to come.
After the USA match in Kobe, England play Argentina and France in Pool C that has been dubbed this tournament's 'group of death'.
Jones has warned his men not to take the USA lightly though, bizarrely saying it would be like facing "15 Donald Trumps".
USA coach Gary Gold retorted: "I've absolutely no idea what he means by that."
Kick off on Thursday is at 12:15 SA time.
15 Elliot Daly; 14 Ruaridh McConnochie, 13 Jonathan Joseph, 12 Piers Francis, 11 Joe Cokanasiga; 10 George Ford (capt), 9 Willi Heinz; 8 Billy Vunipola, 7 Lewis Ludlam, 6 Tom Curry; 5 George Kruis, 4 Joe Launchbury; 3 Dan Cole, 2 Luke Cowan-Dickie, 1 Joe Marler
Substitutes: 16 Jack Singleton, 17 Ellis Genge, 18 Kyle Sinckler, 19 Courtney Lawes, 20 Mark Wilson, 21 Ben Youngs, 22 Owen Farrell, 23 Anthony Watson