Cape Town - Eben Etzebeth will become the 32nd Springbok - and youngest - to reach the 50-Test milestone when he runs out at Suncorp Stadium on Saturday.
Etzebeth, 24, made his Test debut at the age of 20 against England in Durban in 2012 and has since established himself as the Springboks' first-choice No 4.
So who are the other 31 players to have played 50 Tests in the Green and Gold?
Victor Matfield - 127
Bryan Habana - 119
John Smit - 111
Jean de Villiers - 109
Percy Montgomery - 102
Joost van der Westhuizen - 89
Ruan Pienaar - 88
Schalk Burger - 86
Bakkies Botha - 85
Os du Randt - 80
Tendai Mtawarira - 80
Bismarck du Plessis - 79
Mark Andrews - 77
Fourie du Preez - 76
CJ van der Linde - 75
Jaque Fourie - 72
Juan Smith - 70
Jannie du Plessis - 70
JP Pietersen - 69
André Venter - 66
Breyton Paulse - 64
Danie Rossouw - 63
Morné Steyn - 62
Adriaan Strauss - 59
Ollie le Roux - 54
Pierre Spies - 53
Francois Steyn - 53
Gurthrö Steenkamp - 53
Joe van Niekerk - 52
Albert van den Berg - 51
Patrick Lambie - 51