He was 59-years-old.
Visagie played at scrumhalf and flyhalf for Natal in the 1980s and also represented the Springboks on two occasions.
Visagie was nominated for SA Rugby Young Player of the Year in 1979.
The Sharks, former Proteas spinner Pat Symcox and ex-Springbok flank Rob Louw were all quick to convey their condolences on Twitter on Wednesday.
The Sharks & KZNRU are deeply saddened by the passing of former Natal scrumhalf Gawie Visagie. http://t.co/g818GXV7dO pic.twitter.com/zw3tuNuUk2
— The Sharks (@TheSharksZA) November 19, 2014
My dear friend,Springbok rugby player & wonderful man has passed away.No more pain & http://t.co/pllt8cVSGl Gawie Visagie.God speed my bud.
— Pat Symcox (@PatSymcox77) November 19, 2014
So sad one of the nicest Boks always happy always smilling Gawie Visagie has passed away from Cancer !rest well Gavin you were a specialguy!
— Rob Louw (@roblouw6) November 19, 2014