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Goosen will make his return to the field after he injured his shoulder in a Super Rugby match against the Highlanders in Bloemfontein earlier in the season.
He was sidelined for nearly four months after surgery to his shoulder and will make his comeback partnering with scrumhalf Sarel Pretorius.
Goosen was promoted to the starting line-up in the place of Riaan Smit, who dislocated his shoulder in the Cheetahs' 32-18 victory over the Blue Bulls over the weekend.
Smit along with scrumhalf Piet van Zyl, who broke his collarbone, will be sidelined for the rest of the season.
Drotske also included wing Rayno Benjamin in his run-on side while Tewis de Bruyn will be the replacement scrumhalf.
Teams:
Cheetahs: 15 Hennie Daniller, 14 Rayno Benjamin, 13 Robert Ebersohn (captain), 12 Barry Geel, 11 Raymond Rhule, 10 Johan Goosen, 9 Sarel Pretorius, 8 Kabamba Floors, 7 Lappies Labuschagne, 6 Frans Viljoen, 5 Andries Ferreira, 4 Izak van der Westhuizen, 3 Marcel van der Merwe, 2 Hercu Liebenberg, 1 Trevor Nyakane.
Substitutes: 16 Elandre Huggett, 17 Schalk van der Merwe, 18 Francois Uys, 19 Davon Raubenheimer, 20 Tewis du Bruyn, 21 Sias Ebersohn, 22 Nico Scheepers.
Griquas: 15. Willie le Roux, 14. Jannie Boshoff, 13. Stefan Watermeyer, 12. Walter Venter, 11. Rocco Jansen, 10. Francois Brummer, 9. Jacques Coetzee, 8. Leon Karemaker, 7. Justin Downey, 6. Wesley Wilkins, 5. Martin Muller, 4. Ligtoring Landman, 3. Lourens Adriaanse, 2. Ryno Barnes (captain), 1. Steph Roberts
16. Matthew Dobson, 17. Janro van Niekerk, 18. Ivann Espag, 19. Frikkie Spies, 20. Chase Minnaar, 21. Marnus Hugo, 22. Marnitz Boshoff
