Dublin - Ireland lock Iain Henderson has been ruled out of this weekend's Six Nations international against England because of family reasons, the Irish Rugby Football Union announced on Friday.
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Devin Toner will now replace Henderson in the second row, with the experienced forward set to win his 70th cap as Ireland go in search of a Triple Crown following wins over Scotland and Wales in the opening two rounds.
Ireland coach Andy Farrell, the father of England captain Owen Farrell, had initially named an unchanged starting XV on Wednesday following a 24-14 win over Wales in Dublin.
Ultan Dillane will now fill the bench vacancy for Sunday's match created by Toner's promotion into the starting XV.
15 Elliot Daly 14 Jonny May, 13 Manu Tuilagi, 12 Owen Farrell (captain), 11 Jonathan Joseph, 10 George Ford, 9 Ben Youngs, 8 Tom Curry, 7 Sam Underhill, 6 Courtney Lawes, 5 George Kruis, 4 Maro Itoje, 3 Kyle Sinckler, 2 Jamie George, 1 Joe Marler
Substitutes: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Will Stuart, 19 Joe Launchbury, 20 Charlie Ewels, 21 Ben Earl, 22 Willi Heinz, 23 Henry Slade
15 Jordan Larmour, 14 Andrew Conway, 13 Robbie Henshaw, 12 Bundee Aki, 11 Jacob Stockdale, 10 Jonathan Sexton (captain), 9 Conor Murray, 8 CJ Stander, 7 Josh van der Flier, 6 Peter O’Mahony, 5 James Ryan, 4 Devin Toner, 3 Tadhg Furlong, 2 Rob Herring, 1 Cian Healy
Substitutes: 16 Ronan Kelleher, 17 Dave Kilcoyne, 18 Andrew Porter, 19 Ultan Dillane, 20 Caelan Doris, 21 John Cooney, 22 Ross Byrne, 23 Keith Earls