"Immediately after the announcement of where the 2018 Commonwealth Games will be held, we will go in for 2022. It has never been to Africa and so we want to put in a bid," he told reporters.
The host city for the 2018 Commonwealth Games will be announced in November in St Kitts & Nevis.
South Africa was widely expected to bid for the 2020 Olympics but the government decided not to back a bid, saying it wanted to focus on delivering basic services such as water and electricity to all its citizens.
But Sam, president of the South African Sports Confederation and Olympic Committee (SASOC), said there was nothing to stop the country bidding for the 2022 Commonwealth Games.
He told reporters at the 30-day countdown to the 123rd International Olympic Committee Session to be held in Durban in July that South Africa had previously stepped back to allow other countries to bid for the Commonwealth Games.
"In the past we stood back for Nigeria but they lost out to Glasgow (for the right to host the 2014 games). This time we have said there will be no horse-trading, we will put up our hand and see how we go," he said.
Sam added that a bid for the Commonwealth Games would not be hampered by the same issues that affected a possible Olympics bid.
"The scale of the Commonwealth Games is a lot smaller than the Olympics. We will have to have buy-in from a host city and from government, because of security issues, but we are not talking about the expense of an Olympics," he said.