Scott-Efurd, who is based in the USA, has in recent weeks set new national records in both the 1 500m and 3 000m - races in which she will compete in in Birmingham.
The World Indoor Championships take place between March 1-4.
South Africa's team:
Emile Erasmus (60m)‚ Antonio Alkana (60m hurdles)‚ Ruswahl Samaai (long jump)‚ Luvo Manyonga (long jump)
Carina Horn (60m)‚ Dominique Scott-Efurd (1 500m/3 000m)