Cape Town -Multiple national record holder Dominique Scott-Efurd will lead the charge on Thursday when she opens South Africa's campaign at the IAAF World Indoor Championships in Birmingham, England.
The US-based distance runner will line up in the 3 000m women final, taking place at 10:15pm (SA time) in the evening session on Day 1 of the four-day event.
The six-member national team will be eager to shine on Friday, with the men's long jump trio of Luvo Manyonga, Ruswahl Samaai and wild card entry Khotso Mokoena, turning out in a straight final.
Carina Horn will be chasing a place in the 60m women's battle.
Hurdler Antonio Alkana will close out the SA campaign in the 60m men hurdles over the weekend.
The national team will aim to return to the podium for the first time in eight years, following a lengthy medal drought in the indoor format.
Former long jump champion Mokoena, was the last South African to return home with a medal from the global indoor championships, when he earned silver at the 2010 edition in Doha.
"We wish all the athletes a very successful championship in Birmingham. They are there to conquer other athletes from other competing nations and the fly the flag of South Africa high," said Aleck Skhosana, the President of Athletics South Africa.