Khawaja comes in for David Warner, whose wife Candice is expecting the couple’s second child.
Khawaja will join the squad in Brisbane and, at this stage, will remain for matches two and three of the five-game series, at The Gabba (January 15) and in Melbourne, at the Melbourne Cricket Ground (MCG) (January 17).
Commenting on Usman Khawaja’s call-up, National Selector Rod Marsh said: “Usman has been in fantastic form this season and was unlucky to miss out on a place in our squad for the ODI series in the first place.
“This call-up is a reward for that form and it is great to have someone of his quality to step into the squad in David’s absence.
“We wish both David and Candice well and look forward to welcoming David back into the squad when circumstances allow.”