Leeds - Pakistan captain Azhar Ali won the toss and elected to bat against England in the fourth one-day international at Headingley on Thursday.
England made three changes from the side that scored a world ODI record 444 for three in a 169-run win at Trent Bridge on Tuesday as they went 3-0 up in this five-match series.
Wicket-keeper Jonny Bairstow returned on his Yorkshire home ground after Jos Buttler suffered a hamstring injury and was ruled out in the warm-up.
David Willey, Bairstow's Yorkshire team-mate, replaced fast bowler Mark Wood and Chris Jordan took over from fellow all-rounder Chris Woakes.
There were five Yorkshire players in England's XI -- Joe Root, Bairstow, Willey, Liam Plunkett and Adil Rashid.
Pakistan, bidding to avoid a series whitewash, made four changes.
Left-arm quicks Mohammad Amir and Wahab Riaz, together with off-spinning all-rounder Shoaib Malik and leg-spinner Yasir Shah were all left out.
Giant paceman Mohammad Irfan and batsman Mohammad Rizwan were selected for their first match of the series.
Meanwhile spin-bowling all-rounder Imad Wasim returned after his knee injury, with experienced paceman Umar Gul recalled as well.
England have only once completed a whitewash in a one-day series of five matches or more when they won 5-0 away to Zimbabwe in 2001.
England: Alex Hales, Jason Roy, Joe Root, Eoin Morgan (capt), Ben Stokes, Jonny Bairstow (wkt), Moeen Ali, David Willey, Adil Rashid, Liam Plunkett, Chris Jordan
Pakistan: Sami Aslam, Sharjeel Khan, Azhar Ali (capt), Babar Azam, Mohammad Rizwan, Sarfraz Ahmed (wkt), Mohammad Nawaz, Imad Wasim, Umar Gul, Hasan Ali, Mohammad Irfan
Umpires: Marais Erasmus (RSA), Tim Robinson (ENG)
TV umpire: Simon Fry (AUS)
Match referee: Jeff Crowe (NZL)