The Lions have won all three of their matches so far, thanks in no small part to the 214 runs racked up by Chris Gayle, who has dominated every bowling attack that has come his way.
"Our bowlers need to be strong in executing whatever plans we come up with for him," said Cobras captain Justin Ontong.
"It’s an even bigger challenge at the Wanderers, which can be an unforgiving place as a bowler.
"We’ve got to put in a big fielding performance as well - that will be a big part.
"I think he is suspect to run-outs, so if we can run him out early then that will be a big plus-point."
While the Cobras have also enjoyed a good start to the competition, winning two games and then sharing the points with the Knights in Wednesday’s washout, they will have their work cut out for them if the Lions find the extra gear that captain Neil McKenzie believes they still have.
"I don’t think we’ve played our best cricket over these last three games - we’ve probably played at 70 or 75 per cent," McKenzie said.
"There are quite a few areas that we want to work on but it’s pleasing when you still get over the line when you’re not at your best."
While young Proteas seamer, Kagiso Rabada, has returned from Australia and will be part of the Lions squad this weekend, he will not be part of the playing XI as he enjoys a much-needed rest.
Meanwhile, Rory Kleinveldt will not travel with the Cobras after aggravating his groin injury in the lead-up to Wednesday’s abandoned game.
The game gets underway at 18:00 at Wanderers and will be shown live on SuperSport 2.
Since the match is televised, fans attending can participate in the “Win Your Share of a Million competition” by taking a one-handed clean catch.
This competition is open to anybody over the age of 18 and is for South African Citizens only.
Full Terms and conditions for the competition can be found here.