Johannesburg - Pakistan won the toss and sent South Africa in to bat in the second Twenty20 international at the Wanderers Stadium on Sunday.
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Pakistan captain Shoaib Malik said the possibility of rain had influenced his decision to field first despite having failed by six runs in a chase in the opening match in Cape Town on Friday.
Malik said left-arm fast bowler Shaheen Shah Afridi would replace Faheem Ashraf in the Pakistan team. "We were lacking the ability to strike early in the first game," he said.
South Africa fielded two new caps in opening batsman Janneman Malan, 22, and fast bowler Lutho Sipamla, 20.
They replaced captain Faf du Plessis, who is being rested for the final two matches of the series, and batsman-wicketkeeper Gihahn Cloete.
"It will be nice to put a score on the board and put them under pressure," said stand-in captain David Miller, who said South Africa were keen to clinch the three-match series with a game to spare.
Both captains noted that the pitch helped spin bowlers in a women's international match played earlier on the same surface.
South Africa: Janneman Malan, Reeza Hendricks, Rassie van der Dussen, David Miller (captain), Heinrich Klaasen (wicket-keeper), Andile Phehlukwayo, Chris Morris, Lutho Sipamla, Beuran Hendricks, Junior Dala, Tabraiz Shamsi
Pakistan: Fakhar Zaman, Babar Azam, Hussain Talat, Shoaib Malik(captain), Asif Ali, Imad Wasim, Mohammad Rizwan (wicket-keeper), Shadab Khan, Hasan Ali, Shaheen Afridi, Usman Shinwari