Cape Town - David Wiese will join Proteas team-mates Kyle Abbott and Rilee Rossouw by leaving South Africa and signing a three-year Kolpak deal with English county side Sussex.
Chief executive officer of the Titans, Jacques Faul, confirmed the news on their official website on Monday.
Sport24 reported on Saturday that Wiese informed the Titans that he was seeking a Kolpak deal.
The all-rounder will no longer be available for the Proteas in T20s and ODIs, but he will still ply his trade for the Titans.
"David's decision to sign a Kolpak-deal for Sussex is indeed a sad day for us at the franchise and for South Africa," says Faul.
"It is sad because we obviously pride ourselves in being a successful conveyor belt for international players. South Africa is losing the services of a match-winning all-rounder whose tremendous straight hitting and masterful change of pace makes him an asset to any team," Faul remarked.
"We are indebted to David because he has been very frank with us from the start, and he has handled the whole process with professionalism and integrity.
"He has also committed himself to represent the Titans for the rest of his career. He is a whole-hearted performer and a dedicated human being who commands the utmost respect," Faul said.
"We wish David a very successful Kolpak-career for Sussex and trust that he will be a proud flag-bearer of South Africa and the Titans," Faul explained.
“For us, it is disappointing that would not be available for the Proteas in the T20-series against Sri Lanka,” said Faul.
Wiese, 31, has played 20 T20Is for the Proteas, taking 24 wickets and scoring 92 runs with his best performance with the ball being the 5/23 he took against the West Indies in Durban back in 2015.
Wiese currently does not have a Proteas contract.
Meanwhile another Proteas bowler, Marchant de Lange, is also reportedly set to sign a Kolpak deal.
According to Afrikaans weekly, Rapport, De Lange could join Glamorgan, with negotiations between the fast bowler and the English county “at an advanced stage”.
De Lange, 26, has played two Tests, four ODIs and six T20Is for South Africa in an injury-plagued career.
This will be a further blow for Cricket South Africa, who have lost several players to Kolpak deals in recent times.
Batsmen Colin Ingram and Stiaan van Zyl, spinner Simon Harmer and fast bowler Hardus Viljoen are other Proteas players who opted for greener pastures.
Players who sign Kolpak deals in England are unavailable for South Africa in international cricket.