Benoni - Pakistan won the toss and chose to bat in the fifth and final one-day international against South Africa at Willowmoore Park on Sunday.
Pakistan fielded the same team that won the fourth match in Durban by three wickets to level the series at 2-2.
South Africa made two changes. Fast bowler Morné Morkel returned to action for the first time since suffering a hamstring injury in the second Test match last month, replacing Rory Kleinveldt.
South Africa were without opening batsman and Test captain Graeme Smith because of what was described as a chronic left ankle injury which kept him off the field for most of Pakistan's run-chase in Durban.
He was replaced by 20-year-old left-hander Quinton de Kock.
South Africa: AB de Villiers (captain, wicketkeeper), Hashim Amla, Quinton de Kock, Colin Ingram, David Miller, Farhaan Behardien, Ryan McLaren, Robin Peterson, Dale Steyn, Morné Morkel, Lonwabo Tsotsobe.
Pakistan: Misbah-ul-Haq (captain), Mohammad Hafeez, Imran Farhat, Kamran Akmal (wicketkeeper), Younis Khan, Shoaib Malik, Shahid Afridi, Saeed Ajmal, Junaid Khan, Wahab Riaz, Mohammad Irfan.
Umpires: Billy Bowden (NZL), Johan Cloete (RSA)
TV umpire: Kumar Dharmasena (SRI)
Match referee: Andy Pycroft (ZIM)