Muralitharan, the world's leading all-time Test wicket-taker with 800, has played in various Twenty20 competitions since retiring from international cricket in 2011. He is currently playing for the Royal Challengers Bangalore in the Indian Premier League.
In a statement released by organisers, the 41-year-old Muralitharan says "I am good friends with a number of the West Indian players... and having the chance to play on a team with guys competing in their home countries will be fantastic for me."
Six franchised teams will play in the tournament, hosted across the Caribbean from July 29 to August 26. The player draft will be on May 24.