Australia, who have rested middle-order batsmen Marcus North and Callum Ferguson, as well as their most successful limited-overs bowler, Nathan Bracken, willl bat first in perfect conditions and a capacity crowd at the Wanderers is expected to see the runs flowing.
Roelof van der Merwe and Yusuf Abdullah will have to wait for their first tastes of international action and will be carrying the drinks for South Africa along with Justin Ontong and Johann Louw.
South Africa will get their first look at Australian pacemen Brett Geeves and Shane Harwood.
Teams
South Africa - Herschelle Gibbs, Hashim Amla, AB de Villiers, JP Duminy, Vaughn van Jaarsveld, Mark Boucher, Albie Morkel, Robin Peterson, Johan Botha, Wayne Parnell, Dale Steyn.
Australia - David Warner, Brad Haddin, Ricky Ponting, Michael Clarke, Michael Hussey, David Hussey, James Hopes, Cameron White, Mitchell Johnson, Brett Geeves, Shane Harwood.