London - Angelique Kerber crashed out of Wimbledon and lost her hold on the world number one ranking as the German was beaten 4-6, 6-4, 6-4 by Spain's Garbine Muguruza on Monday.
Kerber's fourth round exit extended a miserable run for last year's Wimbledon runner-up, who has failed to make the last eight at any of this year's three majors.
Kerber, the 2016 Wimbledon runner-up, will be replaced at number one by either Karolina Pliskova or Simona Halep.
Muguruza, the 2015 finalist, goes onto play Svetlana Kuznetsova for a place in the last four.
Wimbledon results on Monday, the seventh day of the 2017 championships at the All England Club (x denotes seeding):
Garbie Muguruza (ESP x14) bt Angelique Kerber (GER x1) 4-6, 6-4, 6-4
Svetlana Kuznetsova (RUS x7) bt Agnieszka Radwanska (POL x9) 6-2, 6-4
Magdalna Rybrikov (SVK) bt Petra Martic (CRO) 6-4, 2-6, 6-3
Venus Williams (USA x10) bt Ana Konjuh (CRO x27) 6-3, 6-2
Jelena Ostapenko (LAT x13) bt Elina Svitolina (UKR x4) 6-3, 7-6 (8/6)