London - Russia's Ekaterina Makarova has sent former finalist Agnieszka Radwanska crashing to a surprise exit at Wimbledon on Monday, while giant-killer Barbora Zahlavova Strycova claimed another famous scalp to lead a triple Czech charge into the quarter-finals.
Makarova, the 22nd seed, had never been past the third round in her six previous appearances at Wimbledon, while Polish fourth seed Radwanska made the final in 2012, losing to Serena Williams, and then the last four 12 months ago,
But the 26-year-old, a quarter-finalist at the Australian and French Opens last year, destroyed the world number four on Court Three and will play Czech 23rd seed Lucie Safarova for a place in the semi-finals.
Radwanska's exit means three of the top four seeds have been eliminated from the women's draw following the defeats of Williams and Li Na.
New title favourite, 2004 champion Maria Sharapova will have to come back on Tuesday to play her last-16 tie against Germany's Angelique Kerber after heavy afternoon rain persuaded organisers that there would not be time to get the match completed.
Three of the women's last-16 matches will be played on Tuesday alongside two quarter-final matches, with the other two last-eight fixtures to be staged on Wednesday.
Zahlavova Strycova moved into the last eight with a 6-2, 7-5 victory against former world number one Caroline Wozniacki.
Zahlavova Strycova, the world number 43, had enjoyed the best win of her career in the previous round when she defeated Chinese second seed Li and she added Danish 16th seed Wozniacki to her list of upsets, converting a sixth match point to move into the last eight at a Grand Slam for the first time at the 32nd attempt.
The 28-year-old, who served a six-month ban for doping last year, will play compatriot Petra Kvitova for a place in the semi-finals.
Asked about her revival after the drugs suspension, Zahlavova Strycova admitted she almost quit after testing positive for banned stimulant sibutramine at the 2012 Luxembourg Open.
"I didn't want to play again because I felt like it's a little bit unfair," she said.
"In the first two months, I didn't want to come back. It was tough, but on the other hand, it also brings me some positive things. I am seeing the sport a little bit different now. And here I am."
Czech sixth seed Kvitova, who won the Wimbledon title in 2011, routed world number 61 Peng Shuai of China 6-3, 6-2 in just one hour on Court Two.
The 24-year-old has now reached the last eight at Wimbledon for five successive years.
Three of the four quarter-finalists in the bottom half of the draw are Czech after Safarova ended the fairytale run of world number 175 Tereza Smitkova, a 19-year-old who was the lowest ranked woman left in the tournament, with a 6-0, 6-2 victory in just 47 minutes.
Safarova will face Makarova in her first Wimbledon quarter-final appearance, which will also be the 27-year-old's first last-eight clash at a Grand Slam since 2007.
"We're all playing well. I think it's just the grass suits us definitely," Kvitova said of the impressive Czech performances this year.
Canadian star Eugenie Bouchard booked her first appearance in the quarter-finals as the 13th seed defeated Alize Cornet 7-6 (7/5), 7-5.
The 20-year-old underlined her growing reputation by seeing off French 25th seed Cornet, who had caused one of the great Wimbledon upsets in the previous round when she defeated world number one Williams.
After reaching the semi-finals at the Australian and French Opens already this year, Bouchard, a junior Wimbledon winner in 2012, will aim to make it three in a row at the majors when she faces either Sharapova or Kerber in the last eight.
Sabine Lisicki, last year's beaten finalist, finally downed former world number one Ana Ivanovic on Monday to give herself a place in the last 16.
In a third round match called off for bad light on Saturday, and then interrupted by rain early on Monday, the German 19th seed eventually beat the Serbian 11th seed 6-4, 3-6, 6-1.
She faces Kazakhstan's Yaroslava Shvedova on Tuesday for a place in the quarter-finals.
Wimbledon results on Monday, the seventh day of the 2014 championships at the All England Club (x denotes seeded player):
Novak Djokovic (SRB x1) bt Jo-Wilfried Tsonga (FRA x14) 6-3, 6-4, 7-6 (7/5)
Marin Cilic (CRO x26) bt Jeremy Chardy (FRA) 7-6 (10/8), 6-4, 6-4
Andy Murray (GBR x3) bt Kevin Anderson (RSA x20) 6-4, 6-3, 7-6 (8/6)
Grigor Dimitrov (BUL x11) bt Leonardo Mayer (ARG) 6-4, 7-6 (8/6), 6-2
Stanislas Wawrinka (SUI x5) bt Denis Istomin (UZB) 6-3, 6-3, 6-4
Feliciano Lopez (ESP x19) bt John Isner (USA x9) 6-7 (8/10), 7-6 (8/6), 7-6 (7/3), 7-5
Kei Nishikori (JPN x10) bt Simone Bolelli (ITA) 3-6, 6-3, 4-6, 7-6 (7/4), 6-4
Eugenie Bouchard (CAN x13) bt Alize Cornet (FRA x25) 7-6 (7/5), 7-5
Lucie Safarova (CZE x23) bt Tereza Smitkov (CZE) 6-0, 6-2
Ekaterina Makarova (RUS x22) bt Agnieszka Radwanska (POL x4) 6-3, 6-0
Petra Kvitova (CZE x6) bt Peng Shuai (CHN) 6-3, 6-2
Barbora Zhlavov Strcov (CZE) bt Caroline Wozniacki (DEN x16) 6-2, 7-5
Sabine Lisicki (GER x19) bt Ana Ivanovic (SRB x11) 6-4, 3-6, 6-1
Yaroslava Shvedova (KAZ) bt Madison Keys (USA) 7-6 (9/7), 6-6 - retired