The fourth-seeded Scot found himself in Nadal's side of the draw here on Friday as the line-up for the opening round of the men's singles was confirmed by organisers at Wimbledon.
Second seed Novak Djokovic and six-time Wimbledon champion Roger Federer, seeded three, are on course to meet in the semi-finals after being placed in the opposite side of the draw.
Murray opens against Spanish world number 56 Daniel Gimeno-Traver while Nadal faces American Michael Russell.
Federer opens against Mikhail Kukushkin of Kazakhstan while Djokovic faces France's Jeremy Chardy.
However most interest from Friday's draw surrounded the rematch between American John Isner and France's Nicolas Mahut in a repeat of their marathon 183-game epic at last year's championships.
Isner and Mahut slogged their way into the record books last year when their first round duel became the longest match in tennis history, a gruelling 11-hour and five-minute game over three days.
When it was over, Isner had clinched a 6-4 3-6 6-7 (7/9) 7-6 (7/3) 70-68 first-round victory.
Twelve months later and the two journeymen are set to do it all over again when Wimbledon gets under way next week.
Isner is adamant that the records set in last year's match will never be broken. "It won't happen again," he said recently. "Not even come close."
Meanwhile, since last year's duel Isner and Mahut have become firm friends.
"Honestly, before Wimbledon, we'd never said one word to each other," Isner said of Mahut. "Now we text each other quite often and I've got to know that he's a really class act and a really good guy."
In the women's side of the draw, returning sisters Venus and Serena Williams were kept apart, raising the possibility of a fifth all-Williams final.
The top three women seeds are Caroline Wozniacki, Vera Zvonareva and Li Na, from China, who became the first Asian player to win a grand slam at this month's French Open.
Wozniacki opens against Aranxta Parra Satonja from Spain, while Li, who she could meet in the semi-finals, begins against Russia's Alla Kudryavtseva.
Second seed Zvonareva starts against Alison Riske of the United States.
Wimbledon draw list:
Rafael Nadal (1), Spain, vs. Michael Russell, United States
Pablo Andujar, Spain, vs. Ryan Sweeting, United States
wc-Gilles Muller, Luxembourg, vs. Tommy Haas, Germany
Fabio Fognini, Italy, vs. Milos Raonic (31), Canada
Juan Martin del Potro (24), Argentina, vs. Qualifier
Qualifier, vs. Oliver Rochus, Belgium
Frederico Gil, Portugal, vs. wc-Dudi Sela, Israel
Qualifier, vs. Gilles Simon (15), France
Mardy Fish (10), United States, vs. Marcel Granollers, Spain
Philipp Kohlschreiber, Germany, vs. Denis Istomin, Uzbekistan
Robin Haase, Netherlands, vs. Pere Riba, Spain
Radek Stepanek, Czech Republic, vs. Fernando Verdasco (21), Spain
Juan Ignacio Chela (25), Argentina, vs. Qualifier
Donald Young, United States, vs. Alex Bogomolov Jr., United States
Qualifier, vs. Julien Benneteau, France
Filippo Volandri, Italy, vs. Tomas Berdych, Czech Republic
Andy Murray (4), Britain, vs. Daniel Gimeno-Traver, Spain
Tobias Kamke, Germany, vs. Blaz Kavcic, Slovenia
Sergiy Stakhovsky, Ukraine, vs. wc-Daniel Cox, Britain
Ivan Ljubicic, Croatia, vs. Marin Cilic (27), Croatia
Richard Gasquet (17), France, vs. Santiago Giraldo, Colombia
Igor Kunitsyn, Russia, vs. Qualifier
Qualifier vs. Qualifier
Potito Starace, Italy, vs. Stanislas Wawrinka (14), Switzerland
Gael Monfils (9), France, vs. Matthias Bachinger, Germany
Qualifier vs. Robert Kendrick, United States
wc-Arnaud Clement, France, vs. Qualifier
Ivo Karlovic, Croatia, vs. Janko Tipsarevic (23), Serbia
Thomaz Bellucci (30), Brazil, vs. Rainer Schuettler, Germany
Feliciano Lopez, Spain, vs. Michael Berrer, Germany
Jaroslav Pospisil, Czech Republic, vs. Victor Hanescu, Romania
Qualifier vs. Andy Roddick (8), United States
David Ferrer (7), Spain, vs. Benoit Paire, France
Ivan Dodig, Croatia, vs. Qualifier
Carlos Berlocq, Argentina, vs. Qualifier
Andrey Golubev, Kazakhstan, vs. Guillermo Garcia-Lopez (26), Spain
Alexandr Dolgopolov (22), Ukraine, vs. Fernando Gonzalez, Chile
Qualifier, vs. Ruben Ramirez Hidalgo, Spain
Grigor Dimitrov, Bulgaria, vs. Qualifier
Qualifier, vs. Jo-Wilfried Tsonga, France
Nicolas Almagro (16), Spain, vs. Jarkko Nieminen, Finland
John Isner, United States, vs. Nicolas Mahut, France
Somdev Devvarman, India, vs. Denis Gremelmayr, Germany
Juan Monaco, Argentina, vs. Mikhail Youzhny, Russia
Florent Serra, France, vs. Andreas Haider-Maurer, Austria
Adrian Mannarino, France, vs. Qualifier
Mikhail Kukushkin, Kazakhstan, vs. Roger Federer (3), Switzerland
Robin Soderling (5), Sweden, vs. Philipp Petzschner, Germany
Kei Nishikori, Japan, vs. Lleyton Hewitt, Australia
Igor Andreev, Russia, vs. Teymuraz Gabashvilli, Russia
Qualifier, vs. Nikolay Davydenko (29), Russia
Florian Mayer (20), Germany, vs. wc-Daniel Evans, Britain
Xavier Malisse, Belgium, vs. Mischa Zverev, Germany
Ernests Gulbis, Latvia, vs. Dmitry Tursunov, Russia
wc-Alejandro Falla, Colombia, vs. Jurgen Melzer (11), Austria
Viktor Troicki (13), Serbia, vs. Maximo Gonzalez, Argentina
Yen-hsun Lu, Taiwan, vs. Tommy Robredo, Spain
Ricardo Mello, Brazil, vs. Qualifier
wc-James Ward, Britain, vs. Michael Llodra (19), France
Marcos Baghdatis (32), Cyprus, vs. James Blake, United States
Andreas Seppi, Italy, vs. Albert Montanes, Spain
Kevin Anderson, South Africa, vs. Illya Marchenko, Ukraine
Jeremy Chardy, France, vs. Novak Djokovic (2), Serbia ^Women=
Caroline Wozniacki (1), Denmark, vs. Arantxa Parra Santonja, Spain
Sania Mirza, India, vs. Virginie Razzano, France
Anastasia Rodionova, Australia, vs. Andrea Hlavackova, Czech Republic
Alona Bondarenko, Ukraine, vs. Jarmila Gajdosova, Australia
Dominika Cibulkova (24), Slovakia, vs. Mirjana Lucic, Croatia
Polona Hercog, Slovenia, vs. Johanna Larsson, Sweden
Mathilde Johansson, France, vs. wc-Heather Watson, Britain
Anabel Medina Garrigues, Spain, vs. Julia Goerges (16), Germany
Samantha Stosur (10), Australia, vs. Melinda Czink, Hungary
Anastasiya Yakimova, Belarus, vs. Sofia Arvidsson, Sweden
Elena Baltacha, Britain, vs. Qualifier
Kirsten Flipkens, Belgium, vs. Peng Shuai, China
Lucie Safarova (31), Czech Republic, vs. Lucie Hradecka, Czech Republic
Klara Zakopalova, Czech Republic, vs. wc-Emily Webley-Smith, Britain
Angelique Kerber, Germany, vs. wc-Laura Robson, Britain
Anna Chakvetadze, Russia, vs. Maria Sharapova (5), Russia
Li Na (3), China, vs. Alla Kudryavtseva, Russia
wc-Sabine Lisicki, Germany, vs. Anastasija Sevastova, Latvia
Zheng Jie, China, vs. Zuzana Ondraskova, Czech Republic
Qualifier vs. Bethanie Mattek-Sands, United States
Ana Ivanovic, Serbia, vs. Melanie Oudin, United States
Coco Vandeweghe, United States, vs. wc-Eleni Daniilidou, Greece
Kristina Barrois, Germany, vs. Petra Cetkovska, Czech Republic
Olga Govortsova, Belarus, vs. Agnieszka Radwanska (13), Poland
Marion Bartoli (9), France vs. Qualifier
Lourdes Dominguez Lino, Spain, vs. Romina Oprandi, Italy
Evgeniya Rodina, Russia, vs. Chanelle Scheepers, Netherlands
Irina-Camelia Begu, Romania, vs. Flavia Pennetta (21), Italy
Maria Kirilenko (26), Russia, vs. Alberta Brianti, Italy
Qualifier vs. Yaroslava Shvedova, Kazakhstan
Simona Halep, Romania, vs. Bojana Jovanovski, Serbia
Aravane Rezai, France, vs. Serena Williams (7), United States
Francesca Schiavone (6), Italy, vs. Jelena Dokic, Australia
Barbora Zahlavova Strycova, Czech Republic, vs. Qualifier
Ayumi Morita, Japan, vs. Tamira Paszek, Austria
Christina McHale, United States, vs. Ekaterina Makarova (28), Russia
Shahar Peer (22), Israel, vs. Ksenia Pervak, Russia
Sorana Cirstea, Romania, vs. Pauline Parmentier, France
Qualifier vs. Qualifier
Greta Arn, Germany, vs. Andrea Petkovic (11), Germany
Anastasia Pavlyuchenkova (14), Russia, vs. Qualifier
Vesna Dolonts, Russia, vs. Nadia Petrova, Russia
Kateryna Bondarenko, Ukraine, vs. Alize Cornet, France
Sara Errani, Italy, vs. Kaia Kanepi (17), Estonia
Daniela Hantuchova (25), Slovakia, vs. Qualifier
Qualifier vs. Qualifier
Sandra Zahlavova, Czech Republic, vs. Iveta Benesova, Czech Republic
Magdalena Rybarikova, Slovakia, vs. Victoria Azarenka (4), Belarus
Petra Kvitova (8), Czech Republic, vs. Qualifier
wc-Naomi Broady, Britain, vs. Anne Keothavong, Britain
Rebecca Marino, Canada, vs. Patricia Mayr-Achleitner, Austria
Vera Dushevina, Russia, vs. Roberta Vinci, Italy
Yanina Wickmayer (19), Belgium, vs. Varvara Lepchenko, United States
Anastasia Pivovarova, Russia, vs. Anna Tatishvili, Georgia
Jill Craybas, United States, vs. Alexandra Dulgheru, Romania
Zhang Shuai, China, vs. Svetlana Kuznetsova (12), Russia
Jelena Jankovic (15), Serbia, vs. Maria Jose Martinez Sanchez, Spain
Monica Niculescu, Romania, vs. Sybille Bammer, Austria
wc-Katie O'Brien, Britain, vs. Kimiko Date-Krumm, Japan
Akgul Amanmuradova, Uzbekistan, vs. Venus Williams (23), United States
Tsvetana Pironkova (32), Bulgaria, vs. Qualifier
Vania King, United States, vs. Petra Martic, Croatia
Elena Vesnina, Russia, vs. Laura Pous-Tio, Spain
Alison Riske, United States, vs. Vera Zvonareva (2), Russia