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New York - World number ones Novak Djokovic and Serena Williams were confirmed on Tuesday as the top seeds for the 2013 US Open.
Spain's Rafael Nadal, who returned to number two in the world this week after winning back-to-back Masters titles at Montreal and Cincinnati, is the second seed with reigning men's champion Andy Murray seeded third.
Murray will be defending a Grand Slam title for the first time and also trying to win back-to-back majors for the first time after his triumph at Wimbledon.
Roger Federer, a five-time US Open champion, has dropped to seventh, his lowest seeding at Flushing Meadows since 2002.
Djokovic has reached at least the semi-finals in each of the last six years, and the last time he was the top seed, in 2011, he took home the crown.
Williams, a 16-time Grand Slam champion, is the reigning US Open and French Open champion.
She beat reigning Australian Open titlist Victoria Azarenka in last year's finale in New York, but Azarenka upset Williams in last week's 1-versus-2 WTA final in Cincinnati.
Williams is followed in the seedings by Azarenka, former top-ranked 2006 US Open champ and 2013 French Open runner-up Maria Sharapova, Agnieszka Radwanska, and Sara Errani.
Two-time champion Venus Williams, currently ranked 60th in the world, is unseeded for the tournament that begins on Monday.
Seedings for the 2013 US Open men's tournament:
1. Novak Djokovic, Serbia
2. Rafael Nadal, Spain
3. Andy Murray, Great Britain
4. David Ferrer, Spain
5. Tomas Berdych, Czech Republic
6. Juan Martin Del Potro, Argentina
7. Roger Federer, Switzerland
8. Richard Gasquet, France
9. Stanislas Wawrinka, Switzerland
10. Milos Raonic, Canada
11. Kei Nishikori, Japan
12. Tommy Haas, Germany
13. John Isner, United States
14. Jerzy Janowicz, Poland
15. Nicolas Almagro, Spain
16. Fabio Fognini, Italy
17. Kevin Anderson, South Africa
18. Janko Tipsarevic, Serbia
19. Tommy Robredo, Spain
20. Andreas Seppi, Italy
21. Mikhail Youzhny, Russia
22. Philipp Kohlschreiber, Germany
23. Feliciano Lopez, Spain
24. Benoit Paire, France
25. Grigor Dimitrov, Bulgaria
26. Sam Querrey, United States
27. Fernando Verdasco, Spain
28. Juan Monaco, Argentina
29. Jurgen Melzer, Austria
30. Ernests Gulbis, Latvia
31. Julien Benneteau, France
32. Dmitry Tursunov, Russia
Seedings for the 2013 US Open women's singles tournament:
1. Serena Williams, United States
2. Victoria Azarenka, Belarus
3. Maria Sharapova, Russia
4. Agnieszka Radwanska, Poland
5. Sara Errani, Italy
6. Li Na, China
7. Caroline Wozniacki, Denmark
8. Petra Kvitova, Czech Republic
9. Angelique Kerber, Germany
10. Jelena Jankovic, Serbia
11. Roberta Vinci, Italy
12. Samantha Stosur, Australia
13. Kirsten Flipkens, Belgium
14. Ana Ivanovic, Serbia
15. Maria Kirilenko, Russia
16. Sloane Stephens, United States
17. Sabine Lisicki, Germany
18. Dominika Cibulkova, Slovakia
19. Carla Suarez Navarro, Spain
20. Sorana Cirstea, Romania
21. Nadia Petrova, Russia
22. Simona Halep, Romania
23. Elena Vesnina, Russia
24. Jamie Hampton, United States
25. Ekaterina Makarova, Russia
26. Kaia Kanepi, Estonia
27. Alize Cornet, France
28. Svetlana Kuznetsova, Russia
29. Mona Barthel, Germany
30. Magdalena Rybarikova, Slovakia
31. Laura Robson, Great Britain
32. Klara Zakopalova, Czech Republic
