Cape Town - Kevin Anderson's impressive run at the 2017 French Open is over after the big serving South African was forced to retire in the second set of his Round 4 match against Croatia's Marin Cilic.
Anderson had lost the first set 6-3 and was down 3-0 in the second when he couldn't continue further due to a hamstring injury.
Anderson is the sixth player from the men's draw forced to retire from the tournament.
Cilic will now face Switzerland's Stan Wawrinka in the quarter-finals.
Wawrinka beat home hero Gael Monfils 7-5, 7-6 (9/7), 6-2.
French Open results on Monday, the ninth day of the 2017 tournament at Roland Garros (x denotes seeding):
Andy Murray (GBR x1) bt Karen Khachanov (RUS) 6-3, 6-4, 6-4
Kei Nishikori (JPN x8) bt Fernando Verdasco (ESP) 0-6, 6-4, 6-4, 6-0
Stan Wawrinka (SUI x3) bt Gael Monfils (FRA x15) 7-5, 7-6 (9/7), 6-2
Marin Cilic (CRO x7) bt Kevin Anderson (RSA) 6-3, 3-0 retired
Elina Svitolina (UKR x5) bt Petra Martic (CRO) 4-6, 6-3, 7-5
Simona Halep (ROM x3) bt Carla Suarez Navarro (ESP x21) 6-1, 6-1
Caroline Garcia (FRA x28) bt Alize Cornet (FRA) 6-2, 6-4
Karolina Pliskova (CZE x2) bt Veronica Cepede Royg (PAR) 2-6, 6-3, 6-4