Miami - Top seeds and defending champions Novak Djokovic and Victoria Azarenka advanced on Monday while third seed Roger Federer crashed out of the ATP/WTA Miami Masters tournament.
Djokovic defeated No 27 seed Viktor Troicki 6-3, 6-4 in an all-Serb third round match-up on Monday.
American Andy Roddick upset 16-time major winner Federer 7-6 (7/4), 1-6, 6-4, snapping the Swiss star's win streak at 16 matches.
The world number one Djokovic, who won Miami titles in 2007 and 2011, saved seven of eight break point opportunities as he beat Troicki for the 11th consecutive time.
"Generally I feel that I have been playing well," Djokovic said. "I did have some ups and downs, especially in today's match, but I'm confident that I can raise the level of my performance in every match."
Djokovic finished with two aces, one double fault and won 73 percent of his first-serve points in the 85 minute match.
Djokovic next plays 17th seed Richard Gasquet of France.
Azarenka survived a scare from 16th seeded Dominika Cibulkova, gutting out a 1-6, 7-6 (9/7), 7-5 victory in the fourth round Monday.
Cibulkova made Azarenka, of Belarus, work to protect her season long match win streak which now stands at 26.
"It felt like she closed her eyes and just went for everything, and me, I couldn't really open my eyes," Azarenka said. "It was like I was blinded.
"But my coach came to the court, kicked me a little bit that I have to at least try to change something. It was like a snowball. I kept rolling ... and I didn't really adjust.
"In the end I tried to change something. But it was more about fighting in my heart today."
World No. 1 Azarenka struggled in the first set then needed a tiebreaker in the second to get back into the marathon two hour, 47 minute match. She finished with two aces and seven double faults, compared to Cibulkova's 10 double faults.
Azarenka advances to face France's Marion Bartoli, who easily defeated Maria Kirilenko 6-1, 6-2 earlier in the day.
Roddick beat Federer for just the third time in 24 career meetings.
"It was kind of a game of chess," Roddick said. "I stayed back on the returns, which is something I have not done with him often early on. He might have been a little bit surprised by it."
Roddick hammered 12 aces and won 74 percent of his first-serve points to outlast Federer in the two hour, one minute third round match.
After losing the first set tie-break, Federer broke Roddick three times to even the match at one-set all.
Roddick saved four break points to hold serve in his first service game of the final set.
"I had my chances," Federer said. "I could have been up a break early in the third, but he did well to fight off those break points. He served really well."
Federer's 16-match win streak, included titles in Rotterdam, Dubai and Indian Wells.
World No 2 Maria Sharapova defeated fellow Russian Ekaterina Makarova 6-4, 7-6 (7/3) to set up a quarter-final clash with China's Li Na.
Sharapova, the 2011 Miami runner-up, is chasing her first title at the event after finishing second three times. She lost in the final last year to Azarenka.
"I felt like I was up a set and a break, and played a bit sloppy," Sharapova said. "Combination of her stepping up, and being much more aggressive. She had opportunities, served for the second set.
"I just hung in there and stayed consistent. I played a much smarter tiebreaker, and I think that helped me."
Sharapova saved break point 11 of 15 times and converted on five of eight of her break point opportunities to advance into a match-up against Li, who rallied to beat Sabine Lisicki 3-6, 6-4, 6-2.
American 10th seed Serena Williams defeated Australian sixth seed Samantha Stosur 7-5, 6-3 in a rematch of the 2011 US Open final.
Results on Monday from the $9.6 million ATP and WTA Miami hardcourt tournament (x denotes seed):
Novak Djokovic (SRB x1) bt Viktor Troicki (SRB x27) 6-3, 6-4
Richard Gasquet (FRA x17) bt Albert Ramos (ESP) 6-2, 5-7, 6-3
David Ferrer (ESP x5) bt Julien Benneteau (FRA x30) 7-6 (7/5), 6-4
Nicolas Almagro (ESP x12) bt Fernando Verdasco (ESP x20) 6-3, 6-4
Mardy Fish (USA x8) bt Kevin Anderson (RSA x28) 6-4, 6-3
Juan Martin Del Potro (ARG x11) bt Marin Cilic (CRO x23) 6-3, 7-6 (7/3)
Andy Roddick (USA x31) bt Roger Federer (SUI x3) 7-6 (7/4), 1-6, 6-4
Juan Monaco (ARG x21) bt Gael Monfils (FRA x14) 4-6, 6-3, 6-4
Marion Bartoli (FRA x7) bt Maria Kirilenko (RUS x22) 6-1, 6-2
Agnieszka Radwanska (POL x5) bt Garbine Muguruza (ESP) 6-3, 6-2
Serena Williams (USA x10) bt Samantha Stosur (AUS x6) 7-5, 6-3
Li Na (CHN x8) bt Sabine Lisicki (GER x12) 3-6, 6-4, 6-2
Maria Sharapova (RUS x2) bt Ekaterina Makarova (RUS) 6-4, 7-6 (7/3)
Victoria Azarenka (BLR x1) bt Dominika Cibulkova (SVK x16) 1-6, 7-6 (9/7), 7-5
Caroline Wozniacki (DEN x4) bt Yanina Wickmayer (BEL x23) 7-6 (8/6), 6-0
Venus Williams (USA) bt Ana Ivanovic (SRB x15) 6-7 (4/7), 6-2, 6-2