Cape Town - South Africa's No 1 tennis player, Kevin Anderson, was beaten 7-5, 7-5 in the Nice Open quarter-finals by Portugal's Joao Sousa on Thursday.
The third-seeded Anderson reached the quarter-finals after beating Argentina's Diego Schwartzman 7-6 (7/4), 6-3 earlier in the week.
The 20th-ranked South African has been struggling with various injuries, and underwent ankle surgery in March.
He will now shift his attention to the French Open, which starts in Paris on Sunday.
Results from the fifth day of the ATP Nice Open on Thursday (x denotes seeded player):
Quarter-finals
Dominic Thiem (AUT x1) bt Andreas Seppi (ITA x7) 6-3, 6-3
Adrian Mannarino (FRA) bt Guido Pella (ARG) 5-7, 7-6 (7/4), 6-1
Joao Sousa (POR x5) bt Kevin Anderson (RSA x3) 7-5, 7-5
Alexander Zverev (GER x8) bt Gilles Simon (FRA x2) 6-3, 6-7 (6/8), 7-6 (7/1)