Indian Wells - Japan's world number five Kei Nishikori's run at Indian Wells ended on Wednesday with a 6-4, 7-6 (7/2) loss in the fourth round to Spain's Feliciano Lopez.
Lopez moves through to the quarter-finals where he will face Britain's Andy Murray who beat France's Adrian Mannarino 6-3, 6-3.
Lopez blasted 12 aces, won 82 percent of his first serve points and broke Nishikori twice in the one hour, 35 minute match.
Nishikori was playing his second straight Spaniard after a hard fought 6-7 (6/8), 6-1, 6-4 win over Fernando Verdasco in the previous round.
Nishikori said the turning point was late in the second set.
"I really had one bad game at 5-4. I think until then I was playing better," Nishikori said.
Results at the ATP and WTA BNP Paribas Open tennis tournament on Wednesday (x denotes seeding):
Andy Murray (GBR x4) bt Adrian Mannarino (FRA) 6-3, 6-3
Feliciano Lopez (ESP x12) bt Kei Nishikori (JPN x5) 6-4, 7-6 (7/2)