Portugal climbed to the top of European Championship qualifying Group I with a hard-fought 2-1 win over a resolute Serbia.
Portugal boss Fernando Santos said he was glad Cristiano Ronaldo's return to Old Trafford had been a success.
It will be Ronaldo versus Messi at Old Trafford on Tuesday when Portugal face off against Argentina.
Former Greece manager Fernando Santos has been appointed as Portugal's new head coach, the FPF announced on Tuesday.
Portugal's coach Paulo Bento has decided to quit because of poor results and his replacement will be announced soon.
Sporting Lisbon stamped a €60m buy-out clause on "Baby Messi" after signing the under 21 Scotland international from Dundee United.
Cristiano Ronaldo insists Portugal "gave their all' at the 2014 World Cup, but admits in the end it just wasn't enough to progress.
Cristiano Ronaldo has scored the winner for Portugal as they beat Ghana in Brasilia, but both sides still crashed out of the SWC.
LIVE scoring and interactive commentary on the Soccer World Cup match between Portugal and Ghana.
The Soccer World Cup is a thing of beauty. Millions of fans converge on a country for a month long carnival. But soccer has a sad side.
On the last day of the group stages there are just three spots up for grab in the second round of the World Cup and seven teams pining for them.
Portugal must win big against Ghana and hope Germany and the US do not draw in Recife to have any hope of progressing to the last 16.
Cristiano Ronaldo's Portugal face a sobering early Soccer World Cup exit in their final group game against Ghana.
Moroka Swallows head coach Zeca Marques offers his reaction to Portugal's performance against the USA.
Portugal forward Cristiano Ronaldo says his side's struggles are no real surprise as the team is not as good as many think.