This was revealed at the quarter-final draw which was held at the Wanderers Club in Johannesburg on Thursday.
Moroka Swallows, who beat Mamelodi Sundowns 3-0 in the last 16 stage, host a Pirates side that beat Black Leopards to proceed to this stage of the competition.
Following their victory against Bloemfontein Celtic on Wednesday, Jomo Cosmos were drawn against Wits. They will play their game at the Sinaba Stadium.
Cape side, Santos will host Platinum Stars in Cape Town while Ajax will also play at home against Golden Arrows.
Quarter-final draw:
Moroka Swallows v Orlando PiratesJomo Cosmos v Wits
Santos v Platinum Stars
Ajax Cape Town v Golden Arrows