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Rooney will be absent from the United squad that makes the trip to face West Bromwich Albion at the Hawthorns on the final day of the Premier League campaign, a fixture which marks Ferguson's 1,500th and final game in charge before his retirement.
Coleen, 27, is expecting a boy, a brother to their first child Kai who was born in November 2009, and revealed on her Twitter account that she was now past her Saturday due date.
"Such an uncomfortable sleep last night! #hurryupbaby Looks like its gonna be a nice day today!!" she tweeted.
Rooney also missed United's final home match of the season against Swansea last weekend and Ferguson revealed after his side's 2-1 win that the England striker had asked for a transfer, sparking reports he could join Chelsea or Paris Saint-Germain.
Premier League champions United remain keen to keep Rooney but it is possible that the 27-year-old will never play for the club again.
