Cape Town - City FC will make their debut in the Premiership against Polokwane City at the Cape Town Stadium on Tuesday evening.
The newest club in the league was formed following the purchase of Mpumalanga Black Aces' Premiership status by John Comitis at the end of last season.
Under coach Muhsin Ertugral last season, Aces finished in fourth place with 47 points from 30 games.
City FC, meanwhile, have assembled a squad which is made up of a host of players from the previous Aces squad and a number of new acquisitions.
The club has made several marquee signings in the shape Lehlohonolo Majoro, Tshepo Gumede and Robyn Johannes, and former Orlando Pirates coach Eric Tinkler has been tasked with guiding the team in their maiden season.
Attacking midfielder Lebogang Manyama will lead the team after being appointed captain.
Meanwhile, Polokwane roped in a new coach in the form of Belgian Luc Eymael to replace Brazilian Julio Leal.
Polokwane will look to rectify their leaky defence from last season that conceded 44 goals, the second most in the league.
Rise and Shine will be eager for fare better than their 13th-place finish with 31 points from 30 games.
Looking ahead to his side's Premiership debut, Tinkler said: "The approach is that we are playing at home and we need to dominate and to dictate play.
"We can't go into this game with fear. That what I've been explaining to the players. If anybody needs to show to fear it should be Polokwane City and the shouldn't feel comfortable coming to our home - that's very, very important, you know. We must play attacking football at home.
"You win games by scoring goals and that must become key for us."
Tinkler's opposite number, Luc Eymael, told his side's official website: "The pressure is on the shoulders of Cape Town City FC.
"They are a new team with a new coach and new players which will inevitably translate into big means. Also the added pressure of playing at home, they are faced with a daunting task of having to convince their fans.
"However the boys seem very ready but it will be a tough game and we can't risk the thought of downplaying them."