Cape Town - Mamelodi Sundowns will be hoping to get their title charge back on track when they face SuperSport United at Loftus Versveld on Thursday.
With the league entering the business end of the campaign, the Tshwane derby takes on an extra bit of significance for both title rivals.
Matsatsantsa still have a mathematical chance of winning the title, while defending champions Sundowns - games in hand and all - will be keen to get back on the winning run and put up a fight as they look to retain the trophy.
Stuart Baxter's side enter the match on the back of shock 1-0 loss to relegation-threatened Baroka FC, and for captain Dean Furman, the derby is about getting back on track.
"We know how important this game is for our Absa Premiership aspirations," Furman was quoted by KickOff website.
"We want to get back up to the top of the table and we'll definitely be going for the win."
For Sundowns, the fixture could not come at a worse time. They have come back down to earth in a hard way recently after an impressive year which saw them conquer the African continent.
Brazilians coach Pitso Mosimane admitted that the recent blip was bound to happen due to the club going through two seasons without some time off - as they are now winless in their last five games across all competitions.
"I don't know if we can go through another season without proper preparation," Mosimane said.
"We can't play football continuously for two years and only have three weeks' break. It's not going to work."
Sundowns have a host of injury problems to deal with; Ricardo Nascimento and Soumahoro Bangaly are the latest to join Wayne Arendse, Tiyani Mabunda, Dennis Onyango, Sibusiso Vilakazi and Asavela Mbekile on the sidelines.
Kick off is at 18:00.