Johannesburg - Goalkeeper Moeneeb Josephs is in line to make his first start of the season when Wits host AmaZulu in the Absa Premiership.
Read: Wits out to down AmaZulu
The experienced Bafana Bafana goalkeeper has been sidelined since pre-season after picking up a leg injury, with Jackson Mabokgwane and Rowen Fernandez standing in as his replacements.
Defender Onismor Bhasera, though, is suspended for the clash, while attackers Papy Faty and Calvin Kadi remain long-term absentees.
The Students are currently fourth on the table, having won three out of their opening six league fixtures, but are already eight points behind leaders Kaizer Chiefs.
In head-to-head stats, Wits and Craig Rosslee's side have met in 51 league matches since 1985.
The Clever Boys have 19 wins compared to 12 for Usuthu, while 20 matches have been drawn.
Wits have won 13 of their 26 home matches against AmaZulu, suffering just five defeats down the years.
Last season the Johannesburg side took four points off their Durban counterparts, drawing 1-1 in Gauteng before a 1-0 win in the return match in KwaZulu-Natal.
Kick-Off is scheduled for Friday, September 26 at 20:00.