The showpiece decider will be staged at Soweto's Orlando Stadium, with Swallows based at nearby Dobsonville Stadium.
The Premier Soccer League announced the venue on Monday.
Acting CEO, Cambridge Mokanyane, said: "We are extremely excited to announce Orlando Stadium as the venue for the MTN8. We have already seen quality football during the quarter-finals and the semi-finals of the MTN8.
"I have no doubt that this final will produce another spectacular experience for South African football fans.
"Together with our partners MTN we will pull all stops to ensure that we put together a great event that will leave lasting memories on the minds and hearts of our supporters."
Orlando Stadium hosted the event's final in 2009, with Golden Arrows thrashing Ajax Cape Town 6-0 on that occasio
Orlando Stadium will host the MTN8 cup final on September 22, the Premier Soccer League announced on Monday.
SuperSport United and Moroka Swallows will square off in Soweto for the R8 million winner-takes-all prize.