The Iron Duke will serve on a global subcommittee that includes playing greats Pele, Roger Milla of Cameroon, Ghana's Abedi Pele and Portuguese legend Eusebio.
Khoza, who served as chairman of the 2010 FIFA World Cup Local Organising Committee, is already a member of a strategic body headed by FIFA president Sepp Blatter.
It is unclear at this stage what the latest position entails.
"This is a great honour for me and the PSL to be asked by the world governing body to serve on the football committee," Khoza was quoted as saying by the Sowetan.
"It is a motion of confidence in the PSL by FIFA. Our league continues to grow as one of the top premier leagues in the world.
"I will make a contribution and also gain experience by serving on the committee where I will be working with people of illustrious careers in football.
"I appreciate this recognition by FIFA," said Khoza, who earlier on this year was included in the CAF club football committee.
The FIFA committee will have its first meeting on January 9.