Cape Town - Eternal rivals Manchester United and Liverpool were drawn together in the Europa League last 16 in Nyon on Friday.
It is the first time the two most successful teams in English history have been drawn together in European competition.
United have won the English title 20 times and the Champions League three times, compared to 18 and five for Liverpool.
Between the pair they have won 18 European trophies, including the Super Cup.
The plum tie of the round will see United, who have never won the competition, head to Anfield on March 10 before hosting the Reds at Old Trafford a week later.
Three-time former winners Liverpool last won the competition in its previous guise as the UEFA Cup in 2001.
In another single-country draw, former Manchester United full-back Gary Neville's Valencia will take on Athletic Bilbao.
Holders Sevilla faced a kinder draw against Basel, where this season's final will be held, but there was nothing kind about Borussia Dortmund being paired with Tottenham Hotspur.
Europa League last-16 fixtures:
Shakhtar Donetsk v Anderlecht
FC Basel v Sevilla FC
Villarreal v Bayer Laverkusen
Atletico Bilbao v Valencia
Liverpool v Manchester United
Sparta Praha v Lazio
Borussia Dortmund v Tottenham Hotspur
Fenerbache v Braga