Lisbon - Portugal midfielder Joao Mario will miss the upcoming Confederations Cup with a calf muscle injury, the Portuguese Football Federation (FPF) has confirmed.
The Inter Milan player featured in a 4-0 friendly win at home to Cyprus last weekend but will now sit out Friday's trip to Latvia in a World Cup qualifier and the Confederations Cup.
The tournament begins in Russia on June 17 with the European champions facing Mexico in their opening game in Kazan the following day.
Joao Mario's withdrawal leaves Portugal with a squad of 23 including Cristiano Ronaldo, who joined up with his team-mates on Tuesday evening, fresh from helping Real Madrid win the Champions League last weekend.