Nyon - Manchester United will take on Saint-Etienne in the last 32 of the Europa League, with Jose Mourinho's side hosting the French club in the first leg, after Monday's draw.
The tie will see United and France midfielder Paul Pogba, the world's most expensive player, come up against his elder brother Florentin, the Guinea international defender.
The teams met in the now defunct Cup Winners' Cup first round in 1977, with United winning 3-1 on aggregate.
On that occasion, United were forced to host the second leg in the southern English city of Plymouth, 450 kilometres away, following crowd trouble in the first leg in France.
Mourinho's men finished second in Group A behind Fenerbahce while Saint-Etienne topped Group C.
The other Premier League representative, Tottenham Hotspur, will face Gent of Belgium after being eliminated from the Champions League.
Villarreal of Spain will face Italian giants Roma in one of the standout ties, while Bundesliga club Borussia Moenchengladbach were drawn against Fiorentina of Italy.
The first legs will be played on Thursday, February 16, with the return matches a week later.
The Europa League draw for the Round of 32:
Athletic Bilbao v Apoel FC
Legia Warszaw v Ajax
Anderlecht v Zenit
FC Astra Giurgiu vs KRC Genk
Manchester United v St-Etienne
Villarreal v AS Roma
Ludogorets v FC Copenhagen
Celta Vigo v Shakhtar Donetsk
Olympiacos v Osmanlispor
KAA Gent v Tottenham
FC Rostov v Sparta Prague
Krasnodar v Fenerbahce
Borussia Monchengladbach v Fiorentina
AZ Alkmaar v Lyon
Hapoel Be’er Sheva v Besiktas
PAOK FC v Schalke