Madrid - Real Madrid must negotiate a huge April programme including clashes with Atletico Madrid, Bayern Munich and Barcelona without Raphael Varane, who was diagnosed with a hamstring tear on Tuesday.
"After the tests performed today on our player Raphael Varane... he has been diagnosed with a grade two muscle tear in the left hamstring," Madrid said in a statement.
The club didn't specify how long the key centre-back might be out, but Spanish media reports suggest he will be sidelined for at least a month.
Varane returned from a month out with a similar problem in Sunday's 3-0 win over Alaves, but had to be replaced inside the first 10 minutes due to a recurrence of the injury.
The French international will miss Atletico's visit to the Santiago Bernabeu on Saturday as well as both legs of Real's Champions League quarter-final against Bayern Munich before Barcelona's visit to the Spanish capital on April 23.