London - Tottenham defender Jan Vertonghen sustained ligament damage to his left ankle in their 4-0 win over West Bromwich Albion on Saturday.
The centerback was in distress after the incident at White Hart Lane, with scans indicating a ligament tear between grades two and three leaving the Belgian facing a stint on the sidelines until the end of March.
Tottenham boss Mauricio Pochettino said at the time that the injury "looked very bad."
The 29-year-old's injury deals a blow to Tottenham’s title bid.
Vertonghen has played 20 of 21 Premier League games for Tottenham this season, part of a defensive setup who have conceded just 14 goals, the best in the league.
“Thanks to everyone for your kind messages. Gutted to be injured but will be back as soon as I can,” Vertonghen said on Twitter.
Pochettino will need to reshuffle his defense with an important game against Manchester City this weekend and their fourth-round FA Cup game against Wycombe on January 28.
They also play both Europa League legs against KAA Gent in the time the Belgian is scheduled to be out of action.
Pochettino might bring in Ben Davies or Kevin Wimmer as replacements.
Tottenham are second in the Premier League table, seven points behind Chelsea, but are in top form having won seven consecutive games in all competitions.
Kick off is at 19:30.