That is the view of our resident experts, most of whom tip a 1-1 share of the spoils; remember that the Reds come off a thrilling 5-4 triumph over Norwich, also on enemy terrain.
But considering the Foxes hold a three-point lead over both Manchester City and Arsenal, a draw would be enough to keep them at the head of the pack regardless of other midweek outcomes.
Each round of the 2015/16 Premiership campaign, a group of our staff has a crack at predicting the results - do the exercise yourself, if you like, and see how you compare afterwards.
Compiled by Rob Houwing (Newcastle-partial), the others are Garrin Lambley (Everton), Herman Mostert (Chelsea), and a trio of Manchester United devotees in Tashreeq Vardien, Lloyd Burnard and Maano Nekhavhambe.
Three points are awarded for an entirely correct scoreline, and one for right result.
OUR FORECASTS:
ARSENAL v SOUTHAMPTON
Tuesday, 21:45
Rob: 2-0
Garrin: 2-1
Herman: 2-1
Tashreeq: 1-0
Lloyd: 3-1
Maano:2-1
Last season: 1-0
LEICESTER v LIVERPOOL
Tuesday, 21:45
Rob: 1-1
Garrin: 1-1
Herman: 2-1
Tashreeq: 2-1
Lloyd: 1-1
Maano: 1-1
Last season: 1-3
NORWICH v TOTTENHAM
Tuesday, 21:45
Rob: 0-1
Garrin: 1-2
Herman: 1-2
Tashreeq: 0-2
Lloyd: 1-3
Maano: 0-1
Last season: Not applicable
SUNDERLAND v MANCHESTER CITY
Tuesday, 21:45
Rob: 0-1
Garrin: 0-2
Herman: 1-2
Tashreeq: 1-2
Lloyd: 0-2
Maano: 0-1
Last season: 1-4
WEST HAM v ASTON VILLA
Tuesday, 21:45
Rob: 2-0
Garrin: 2-1
Herman: 2-0
Tashreeq: 3-2
Lloyd: 2-1
Maano: 0-0
Last season: 0-0
CRYSTAL PALACE v BOURNEMOUTH
Tuesday, 22:00
Rob: 1-1
Garrin: 2-1
Herman: 1-1
Tashreeq: 1-0
Lloyd: 1-1
Maano: 1-0
Last season: Not applicable
MANCHESTER UNITED v STOKE
Tuesday, 22:00
Rob: 2-0
Garrin: 2-1
Herman: 2-1
Tashreeq: 1-0
Lloyd: 0-0
Maano: 1-0
Last season: 2-1
WEST BROM v SWANSEA
Tuesday, 22:00
Rob: 2-2
Garrin: 1-1
Herman: 1-1
Tashreeq: 1-1
Lloyd: 1-1
Maano: 0-2
Last season: 2-0
EVERTON v NEWCASTLE
Wednesday, 21:45
Rob: 2-1
Garrin: 2-1
Herman: 2-1
Tashreeq: 1-1
Lloyd: 2-1
Maano: 2-1
Last season: 3-0
WATFORD v CHELSEA
Wednesday, 21:45
Rob: 0-1
Garrin: 1-2
Herman: 1-2
Tashreeq: 1-3
Lloyd: 0-2
Maano: 0-1
Last season: Not applicable
*LEADERBOARD:
163 - Maano (6 points in last round)
147 - Garrin (6)
134 - Tashreeq (3)
133 - Rob (1)
129 - Herman (5)
128 - Lloyd (3)