His bitter rival from his days in charge of Real Madrid in Spain, former Barcelona boss Pep Guardiola now in charge of city rivals Manchester City, will host Sunderland, who just escaped the drop last season.
Current Italy coach Antonio Conte faces a highly-charged first game in the dugout for Chelsea as he has a London derby with Slaven Bilic's West Ham.
Another of the influx of top class continental European coaches, Jurgen Klopp, will begin his first full season in charge - having replaced Brendan Rodgers in the middle of last term - by taking his Liverpool outfit to face French veteran Arsene Wenger's Arsenal.
Champions Leicester have a gentle start away at newly-promoted Hull, but then have their credentials tested to the full when they host the Gunners, who finished runners-up, the week after.
Two former Southampton bosses will trade blows on the pitch as Ronald Koeman's first taste as Everton manager will be to host Spurs, coached by his predecessor at Saints, Mauricio Pochettino.
Only a year ago Koeman criticised Pochettino for ditching Southampton before his contract was up - only for Koeman to do the same thing when he took the Everton job on Tuesday.
Opening weekend: August 13-15
Bournemouth v Manchester United
Arsenal v Liverpool
Burnley v Swansea City
Chelsea v West Ham United
Crystal Palace v West Bromwich Albion
Everton v Tottenham Hotspur
Hull City v Leicester City
Manchester City v Sunderland
Middlesbrough v Stoke City
Southampton v Watford
First BIG MATCH fixtures:
Manchester United v Manchester City - September 10
Arsenal v Chelsea - September 24
Liverpool v Manchester United - October 15
Chelsea v Manchester United - October 22
Arsenal v Tottenham Hotspur - November 5
Everton v Liverpool - December 17
Liverpool v Manchester City - December 31
Last Weekend: May 21
Arsenal v Everton
Burnley v West Ham United
Chelsea v Sunderland
Hull City v Tottenham Hotspur
Leicester City v Bournemouth
Liverpool v Middlesbrough
Manchester United v Crystal Palace
Southampton v Stoke City
Swansea City v West Bromwich Albion
Watford v Manchester City