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London - Tottenham Hotspur manager Mauricio Pochettino said Toby Alderweireld and Harry Kane were unlikely to play against Arsenal on Sunday.
"The result doesn't change our idea," Pochettino said of Kane's availability.
"We said yesterday he might be available, but to play from the beginning is difficult."
The Argentine said Alderweireld's situation was "difficult."
Kane picked up an ankle ligament injury in Tottenham's win over Sunderland on September 18, while Alderweireld sustained a knee injury in a collision with teammate Jan Vertonghen.
The pair have not played for more than two weeks, but were tipped to return for the game at Emirates Stadium.
Pochettino earlier said Kane was likely to play after returning to first-team training this week.
Moussa Dembele is also in doubt with an ankle injury, which - if he does not play - would leave them short of midfield options.
Spurs' loss to Bayer 04 Leverkusen in the Champions League means they have gone winless for six games on the trot.
In the Premier League they have drawn their past three games.
The London derby is set for a 14:00 kick off.
