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London - Chelsea opened up a four-point lead at the top of the Premier League after Didier Drogba's double inspired a 2-0 win at Wolves and Everton claimed a 3-1 victory over Manchester United on Saturday.
Carlo Ancelotti's Chelsea have often dropped points on their travels this season but in-form Drogba, who has six goals in five games since returning from the African Nations Cup, ensured the Blues were able to take advantage of United's slip.
In the day's early kick-off, United looked lethargic after their mid-week victory against AC Milan and slumped to their first defeat in nine league games.
Dimitar Berbatov put Sir Alex Ferguson's team ahead in the 16th minute when he controlled Antonio Valencia's cross perfectly before smashing a close-range shot past Tim Howard.
But United's lead was short-lived as Russian winger Diniyar Bilyaletdinov drove a vicious swerving effort past Edwin van der Sar from 25 yards.
United struggled to find any momentum after that and David Moyes's team took the lead in the 76th minute.
South African midfielder Steven Pienaar whipped over a low cross for substitute Dan Gosling to steer in just his second goal of the season.
Jack Rodwell ensured United would suffer their sixth league defeat of the season in the 90th minute as he surged away from Jonny Evans and drove his shot into the far corner.
"We were well beaten, simple as that," Ferguson said. "We started the game well enough, but their goal galvanised them and gave them the incentive.
"This is a bad result and at this time of the year we can't afford results like that."
At Molineux, Chelsea struggled in the early stages but finally pieced together an incisive move to take the lead in the 40th minute.
Yuri Zhirkov exchanged passes with Michael Ballack and the Russian crossed for Ivory Coast striker Drogba to slot home.
Drogba took his goal total for the season to 25 in the 67th minute when poor defending from Christophe Berra allowed him to reach Petr Cech's long punt, round goalkeeper Marcus Hahnemann and drive in his 25th goal of the season.
Third placed Arsenal are just two points behind United after a 2-0 win against Sunderland at the Emirates Stadium.
Arsene Wenger's team made the breakthrough in the 27th minute when Denmark striker Nicklas Bendtner tapped-in Emmanuel Eboue's cross for his first goal since October.
Sunderland have now gone 11 league matches without a win and Arsenal goalkeepr Manuel Almunia, back in for Lukasz Fabianski after the Pole's midweek blunders against Porto, was rarely tested following Bendtner's strike.
Gunners captain Cesc Fabregas stroked home a 90th minute penalty after the Spaniard was bundled over by Fraizer Campbell.
West Ham boosted their survival bid with a 3-0 win over fellow strugglers Hull at Upton Park.
Gianfranco Zola's team got off to the perfect start as Swiss midfielder Valon Behrami fired home from Guillermo Franco's flick in the third minute.
Hull's task was made even harder when midfielder Craig Fagan was sent off for a second bookable offence after tugging Alessandro Diamanti early in the second half.
And England forward Carlton Cole sealed it in the 59th minute with a clinical finish that moved the Hammers four points clear of the relegation zone.
Julien Faubert had set up Cole's goal and he added West Ham's third himself in the 90th minute.
