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Johannesburg - Newcastle United will also lose the services of an in-form striker, with Papiss Cisse having been called up by Senegal, but he was due to serve a three-match ban anyway for elbowing Everton's Seamus Coleman.
Newcastle, currently without a manager following the departure of Alan Pardew, must also cede Ivorian midfielder Cheick Tiote.
West Ham United will lose Senegalese midfielder Cheikhou Kouyate, but his compatriot Diafra Sakho, who has scored nine goals since signing from Metz, has been ruled out of the tournament by a back injury.
On-loan midfielder Alex Song will also not be taking part in the tournament after being omitted from Cameroon's squad, which prompted him to announce his international retirement at the age of 27.
Bottom club Leicester City must do without Algerian winger Riyad Mahrez, who has had an influential role in the team's improved recent form, but Ghanaian full-back Jeff Schlupp stays behind.
Other Premier League players scheduled to compete in Equatorial Guinea include livewire Crystal Palace winger Yannick Bolasie (Democratic Republic of Congo), Liverpool centre-back Kolo Toure (Ivory Coast), Stoke City striker Mame Biram Diouf (Senegal) and young Tottenham Hotspur midfielder Nabil Bentaleb (Algeria).
Hull City's Senegalese midfielder Mohamed Diame will miss the tournament through injury, but Senegal have put themselves at loggerheads with Southampton by calling up winger Sadio Mane despite the fact he is currently sidelined with a calf problem.
Two of the biggest African names in English football will not be competing, with Chelsea's Ivorian veteran Didier Drogba and Cameroonian great Samuel Eto'o of Everton having retired from the international game.
Chelsea midfielder John Mikel Obi (Nigeria), Southampton enforcer Victor Wanyama (Kenya) and West Bromwich Albion schemer Stephane Sessegnon (Benin) play for countries that did not qualify.
Eight teams, meanwhile, will be untouched by the tournament, including Chelsea, Arsenal and Manchester United.
