Cape Town - New signing Mathieu Debuchy will miss the next six weeks, at least, after injuring his ankle against Manchester City.
BBC report that Mathieu Debuchy's injury may require surgery which would further delay his return.
"He has an exploration of his ankle on Friday night. They go in and look how the ligament is damaged." said Wenger.
Debuchy could miss three months of action if the medical staff believe surgery is required.
Arsenal, who were held by City in their last fixture, will now rely on 19-year-old Calum Chambers to slot in at right back.
Chambers was on the bench during the Gunners midweek Champions League loss away at Dortmund. The former Southampton player has been struck down by tonsillitis but is expected to take his place in the starting lineup against Aston Villa.
Aston Villa host Arsenal on Saturday, September 20 off the back of a shock 1-0 win at Anfield last weekend with Paul Lambert's side flying high in second spot on the English Premiership log.
The match kicks off at Villa Park at 16:00.
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