McCarthy and Ndlovu suffered a hamstring and a dislocated shoulder respectively in South Africa's 1-0 loss to Brazil on Friday at the Estadio do Morumbi Stadium in Sao Paolo Brazil.
The duo has since been released from the squad.
"It is sad that we have lost the two players but it is part of the game there's not much we can do but wish them a speedy recovery," Igesund said.
"We have only one training session on Monday so it doesn't help to bring in any replacements.
"The situation also gives me a chance to see and work with the players in the squad who did not get an opportunity against Brazil and I am confident they will raise their hands when given the opportunity."
England-based midfielder Kagiso Dikgacoi has also been released to return to his club, leaving Igesund with 21 players to work with.
Bafana has already arrived in Nelspruit to complete preparations ahead of the Mozambique encounter at the Mbombela Stadium.
Follow Sport24 on Twitter and Facebook
24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.
A mandate is a mandate. Fire him!
Give him another chance! Give him another chance!
Put it to a public vote to decide on who should take charge of Bafana
View Results | Vote Archive
16% A mandate is a mandate. Fire him!
73% Give him another chance! Give him another chance!
11% Put it to a public vote to decide on who should take charge of Bafana
Vote Archive
GEN De La Rey says the Stormers have had a pretty bad run when it comes to refs, assistant refs and TMO calls this season. He says such glaring ref errors have no place in the professional game.
Twitter Follow Sport24 on Twitter
Newsletters Sign up for Sport24's Morning Glory newsletter
Blogs Yes your opinion counts. Get it out there
WIN Enter and win with Sport24!
Mobile Sport24 on your mobile phone - WAP, alerts, downloads, services
BlackBerry Stay in the loop on your BlackBerry
iPhone Latest Sport24 news on your iPhone
Facebook "Like" Sport24's Facebook page
TV schedule Plan your couch time with our searchable sport TV guide
RSS Feeds Sport news delivered really simply.