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The crucial African Nations Cup qualifier will be played at Ellis Park on March 26 and with the duo both enjoying regular game time, their selection comes as no surprise.
The South Africa boss named a squad of 24 and revealed a further eight players were included 'for observation'.
Perhaps the most shocking finding was that Aaron Mokoena was again left out of the squad as he struggles to cement a regular starting spot for Portsmouth.
BidVest Wits attacking midfielder Sifiso Myeni has earned another call-up following some sensational performances for the club in recent fixtures.
He could be one of players Mosimane merely wants to have a look at, but the Bafana boss will have a selection headache in the centre of the park and upfront.
Reneilwe Letsholonyane,Thanduyise Khuboni, Andile Jali and Kagisho Dikgacoi, who are all on form, will be jostling for a place in central midfield.
Davide Somma and Mphela form part of the same squad for the first time and Mosimane was coy on how he would make use of the target men.
The local-based players will assemble for camp on 16 March, with the overseas-placed stars joining them on March 20.
Bafana squad:
Goalkeepers: Itumeleng Khune (Kaizer Chiefs), Wayne Sandilands (Mamelodi Sundowns), Darren Keet (Bidvest Wits).
Defenders: Siboniso Gaxa (Lierse SK, Belgium), Morgan Gould (SuperSport United), Anele Ngcongca (Genk, Belgium), Siyabonga Sangweni, Mzivukile Tom (both Golden Arrows), Bongani Khumalo (Tottenham Hotspur, England), Rueben Cloete (Orlando Pirates).
Midfielders: Siphiwe Tshabalala, Reneilwe Letsholonyane (both Kaizer Chiefs), Sifiso Myeni (Bidvest Wits), Thanduyise Khuboni (Golden Arrows), Steven Pienaar (Tottenham Hotspur), Andile Jali, Tlou Segolela (Orlando Pirates), Daylon Claasen (Lierse SK, Belgium), Kagisho Dikgacoi (Fulham, England), Thulani Serero (Ajax Cape Town)
Strikers: Davide Somma (Leeds United, England), Bernard Parker (Panserraikos), Kermit Erasmus (SuperSport United), Katlego Mphela (Mamelodi Sundowns)
