London - Argentina have made three changes from the side that beat Japan 54-20 to play Wales in Cardiff on Saturday.
Pablo Matera starts on the blindside in place of Tomas Lezana, while Juan Martin Hernandez and Ramiro Moyano will start in the backline instead of Jeronimo De la Fuente and Santiago Cordero.
Lezana and Cordero fall to the bench while De la Fuente misses the cut for the match-day 23 captained at hooker by Agustin Creevy.
"We'll face an injured Wales team that is doing poorly and has lost its last five games," said Pumas coach Daniel Hourcade.
"They're a great team that is having a bad time but who will be seeking to reverse that come Saturday."
Hourcade added: "It'll be a very tough match since they'll play each ball like their last.
"We'll try to play a slower game. They're a team that moves the ball around a lot, with more contact which focuses more on the physical, with a South African style.
It will be the 19th Test between the two teams, Wales having won 11 times to Argentina's six, with one draw.
15 Leigh Halfpenny, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam
Williams, 10 Dan Biggar, 9 Gareth Davies, 8 Ross Moriarty, 7 Justin Tipuric, 6 Sam
Warburton, 5 Alun Wyn Jones, 4 Luke Charteris, 3 Tomas Francis, 2 Ken Owens,
1 Gethin Jenkins (captain)
Substitutes: 16 Scott Baldwin, 17 Nicky Smith, 18 Samson Lee, 19 Cory Hill, 20 James King, 21 Lloyd Williams, 22 Gareth Anscombe, 23 Jamie Roberts
15 Joaquin Tuculet; 14 Matias Moroni, 13 Matias Orlando, 12 Juan Martin Hernandez, 11 Ramiro Moyano; 10 Nicolas Sanchez, 9 Martin Landajo; 8 Facundo Isa, 7 Javier Ortega Desio, 6 Pablo Matera; 5 Matias Alemanno, 4 Guido Petti; 3 Ramiro Herrera, 2 Agustin Creevy (capt), 1 Lucas Noguera
Substitutes: 16 Julian Montoya, 17 Santiago Garcia Botta, 18 Enrique Pieretto, 19 Leonardo Senatore, 20 Tomas Lezana, 21 Tomas Cubelli, 22 Santiago Gonzalez Iglesias, 23 Santiago Cordero