Cardiff - Wales caretaker coach Rob Howley will field three debutants for Saturday's clash against the Barbarians in Cardiff.
Howley has handed Test debuts to Scarlets fullback Liam Williams and prop Rhodri Jones, and teenage Cardiff wing Harry Robinson.
It could also be a landmark occasion for Robinson's Blues team-mate Martyn Williams, who will win his 100th cap if he comes off the bench against a Barbarians team who beat Ireland on Tuesday but lost to England on the weekend.
Williams is set to join Welsh centurions Stephen Jones and Gareth Thomas by reaching the three-figure landmark.
Scarlets hooker Matthew Rees will captain a Wales side that includes locks Alun-Wyn Jones and Ian Evans, plus No 8 Ryan Jones.
There are returns to the Test arena for Ospreys centre Andrew Bishop and flyhalf Dan Biggar, who both played key roles in last Sunday's Celtic League title-clinching victory over European champions Leinster in Dublin.
The bench also includes uncapped Scarlets centre Adam Warren for Wales' final game before embarking on a three-Test tour to Australia.
"We have picked a side on form, with an eye on bringing players through for the future, but very much with the intention of getting the summer campaign off to a winning start," Howley said.
"We have an opportunity against the Barbarians to get an important summer series off to a winning start.
"We are now looking for the next step and a victory on home soil against a formidable Barbarians team before we set off for Australia."
Liam Williams (Scarlets); Harry Robinson (Cardiff Blues), Andrew Bishop (Ospreys), James Hook (Perpignan), Aled Brew (Newport Gwent Dragons); Dan Biggar (Ospreys), Lloyd Williams (Cardiff Blues); Rhys Gill (Saracens), Matthew Rees (Scarlets, capt), Rhodri Jones (Scarlets), Alun Wyn Jones (Ospreys), Ian Evans (Ospreys), Josh Turnbull (Scarlets), Justin Tipuric (Ospreys), Ryan Jones (Ospreys)
Substitutes: Richard Hibbard (Ospreys), Paul James (Ospreys), Aaron Shingler (Scarlets), Martyn Williams (Cardiff Blues), Rhys Webb (Ospreys), Adam Warren (Scarlets), Will Harries (Newport Gwent Dragons)