Cape Town - Chris Kuridrani will start on the left wing for the Reds against the Sharks in Brisbane on Friday.
Kick-off is at 11:40.
Kuridrani replaces Lachie Turner, who has been ruled out due to concussion, in the only change to the team that beat the Rebels 46-29 last weekend.
The Sharks are coming off a controversial 33-18 defeat to the Waratahs in Sydney, their third defeat on tour and sixth straight loss.
The Reds are currently fourth in the Australian Conference and a lowly 14th in the Overall standings.
The Sharks find themselves fourth in the South African Conference, but a slightly elevated 11th in the Overall log, some five points ahead of their opponents, albeit having played an extra match.
Teams:
Reds
15 James O'Connor, 14 Chris Feauai-Sautia, 13 Karmichael Hunt, 12 Samu Kerevi, 11 Chris Kuridrani, 10 Jake McIntyre, 9 Will Genia, 8 Jake Schatz, 7 Liam Gill, 6 Adam Thomson, 5 James Horwill, 4 Rob Simmons, 3 Greg Holmes, 2 James Hanson, 1 James Slipper (captain)
Substitutes: 16 Andrew Ready, 17 Pettowa Paraka, 18 Sam Talakai, 19 Ed O'Donoghue, 20 Lolo Fakaosilea, 21 Nick Frisby, 22 Sam Greene, 23 Ben Tapuai
Sharks
15. Lwazi Mvovo, 14. Odwa Ndungane, 13. JP Pietersen, 12. Frans Steyn, 11. S'bura Sithole, 10. Lionel Cronje, 9. Stefan Ungerer, 8. Renaldo Bothma, 7. Willem Alberts, 6. Marcell Coetzee, 5. Marco Wentzel (captain), 4. Stephan Lewies, 3. Jannie du Plessis, 2. Bismarck du Plessis, 1. Tendai Mtawarira
Substitutes: 16. Franco Marais, 17. Dale Chadwick, 18. Lourens
Adriaanse, 19. Mouritz Botha, 20. Etienne Oosthuizen, 21. Conrad
Hoffmann, 22. Fred Zeilinga, 23. Andre Esterhuizen