Sydney - Wallaby flyhalf Quade Cooper has suffered a new injury setback and is out for eight weeks with a broken shoulder blade, the Reds have said on Saturday.
Cooper fractured his scapula making a tackle in his second game back for the Reds after recovering from a broken collarbone.
It is another blow for the playmaker and his beleaguered province, who have won just one of their opening seven Super Rugby games this season.
The Reds suffered a further injury blow on the eve of their two-game South African tour with Jake Schatz ruled out for at least a month after rupturing a tendon in his elbow after his arm was caught in an awkward position in a ruck.
"The playing group showed incredible resolve to play out 60 minutes of last night's match with just 14 men and still be a shot at winning the match, so I have no doubt they'll take a similar approach to this setback," Reds coach Richard Graham said.
"All we need to worry about is the things we can control, and that is our attitude, preparation and performance."
The Rebels beat the Reds 23-15 on Friday with the match swinging on the 21st minute dismissal of Reds lock James Horwill to leave them playing for the rest of the game a man down.
Former Wallaby skipper Horwill was sent off for the use of a swinging arm in a ruck for his second red card of the season and was subsequently suspended for one match.